Antiproliferative potential, antigenotoxic and phytochemical analysis of infusions of Baccharis dracunculifolia DC. on the cell cycle of Allium cepa L.
DOI:
https://doi.org/10.70151/nnhn4761Keywords:
Broom, Allium cepa test, Medicinal plantsAbstract
Baccharis dracunculifolia DC. is a medicinal specie populary know as broom, and has its use based on the preparation of infusions of the leaves to treat gastric desorders, physical fatigue, lack of apetite, fever diseases, and organic weakness. The study aimed to evaluate the potential antiproliferative, genotoxic and antigenotoxic of two populations of B. dracunculifolia on the Allium cepa L. test and perform the phytochemical analysis of the infusions of dry leaves. The botanical material consisted of leaves of two populations collected in Santa Maria and São Pedro do Sul, which were dried at room temperature. The experiment consisted of nine groups of four bulbs, each group corresponding to a treatment. The bulbs were rooted in water and then subjected to treatments for 24 hours. After this period, the roots of A. cepa were collected and fixed in Carnoy 3:1 for 24 hours and then stored refrigerated in 70% etanol until the preparation of the slides. The determination of phenolic compounds from aqueous extracts was performed by High Performance Liquid Chromatography (HPLC). The data obtained from the analisys of cell proliferation and genotoxicity have been submitted to the Chi-square test (p<0,05%). The results of the A. cepa test showed that aqueous extracts from B. dracunculifolia have antiproliferative and antigenotoxic potential. The cromatographic analysis indicated the presence of p-coumaric acid as major compound.
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