Chemical composition and anticholinesterase evaluation of aerial parts of Crotalaria retusa

Authors

DOI:

https://doi.org/10.70151/3gfe1e75

Keywords:

Crotalaria retusa, volatile constituents, acetylcholinesterase, chemical composition

Abstract

Acetylcholinesterase (AChE) inhibition is considered as a promising strategy for the treatment of neurological disorders. The aim of this research was to determine the chemical composition of the aerial parts of Crotalaria retusa by gas chromatography coupled to mass spectrometry (GC-MS), and evaluate their anticholinesterase and cytotoxic potential against Artemia salina. The main compounds found were trans-hex-2-enal (66.67%) in fresh leaves; in dry leaves benzene acetaldehyde (23.90%), and in fresh flowers 3-ethyl-4-methyl-pent-3-en-2-one (42.80%). The volatile constituents of fresh leaves, hexane and ethanolic extracts, decoction and dichloromethane fraction showed inhibition against AChE. The extracts were found to be nontoxic against Artemia salina, which increases the perspectives of study of the species about new biological activities.

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Author Biographies

  • Layana Karine Farias Lima, Universidade Federal do Piauí

    Programa de Pós-Graduação em Química

    Programa de Pós-Graduação em Ciências Farmacêuticas

  • Maria do Carmo Gomes Lustosa, Universidade Federal do Piauí

    Programa de Pós-Graduação em Química

    Programa de Pós-Graduação em Ciências Farmacêuticas

  • Mahendra Rai, Amravati University

    Department of Biotechnology SGB

  • Wanessa Sales de Almeida, Universidade Federal do Piauí

    Programa de Pós-Graduação em Ciências e Engenharia de Materiais

  • Nilza Campos de Andrade, Universidade Federal do Piauí

    Programa de Pós-Graduação em Química

    Programa de Pós-Graduação em Ciências Farmacêuticas

  • Chistiane Mendes Feitosa, Universidade Federal do Piauí

    Programa de Pós-Graduação em Química

    Programa de Pós-Graduação em Ciências Farmacêuticas

  • Sidney Gonçalo de Lima, Universidade Federal do Piauí

    Programa de Pós-Graduação em Química

    Programa de Pós-Graduação em Ciências Farmacêuticas

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Published

2024-09-17

Issue

Vol. 23 No. 1 (2021)

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Articles

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How to Cite

Chemical composition and anticholinesterase evaluation of aerial parts of Crotalaria retusa. (2024). Revista Brasileira De Plantas Medicinais Brazilian Journal of Medicinal Plants, 23(1), 1-11. https://doi.org/10.70151/3gfe1e75