Chemical constituents and biological study of Aspidosperma nitidum
DOI:
https://doi.org/10.70151/ph1qd630Keywords:
Apocynaceae, Aspidosperma nitidum, β-carbolinic alkaloid, harman-3-carboxylic acid, anti-inflammatory activitiesAbstract
Chemical constituents and biological study of Aspidosperma nitidum. This work describes the phytochemical study as well as the antinociceptive and anti-inflammatory actions of the ethanolic extract of the Aspidosperma nitidum Benth ex Müll. Arg. (Apocynaceae) wood, species very used in the Amazonian popular medicine for the anti-inflammatory treatment, besides fever and malaria. The phytochemical study of A. nitidum has led to the isolation of the mixture of steroids (β-sitosterol and stigmasterol), pentacyclic triterpenes (β-amirine and lupeol), L-2-O-methyl-chiro-inositol and a β-carbolinic alkaloid, the harman-3-carboxylic acid. The ethanolic extract has showed antinociceptive and anti-inflammatory activities.
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