Popular use and pharmacological actions of Plectranthus barbatus Andr. (Lamiaceae): revision of the works published from 1970 to 2003
DOI:
https://doi.org/10.70151/ga7gd917Keywords:
Plectranthus barbatus, medicinal plants, pharmacologyAbstract
Despite the main use of Plectranthus barbatus Andr. for gastric disturbances, a great number of pharmacological actions were tested and confirmed for this species, involving compounds from leaves, stem and roots. Among the pharmacological aspects already studied and confirmed are: hypotensive, positive inotropic, cardiovascular, bronchodilator, adenylate cyclase activation, platelet aggregation inhibition, antitumoral, antinociceptive and anti-inflammatory. In order to contribute for a better knowledge of this species we present a revision of the main publications involving chemical and pharmacological studies published from 1970 to 2003.
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AGARWAL, K.C.; PARKS JR., R.E. Synergistic inhibition of platelet aggregation by forkolin plus PGE1 or 2 - fluoroadenosine: effects of 2', 5' - dideoxyadenosine and 5' - methylthioadenosine. Biochemical Pharmacology, v.31, n.22, p.3713-6, 1982.
AGARWAL, K.C.; PARKS JR., R.E. Forskolin: a pontetial antimetastic agent. International Journal of Cancer, v.32, p.801-4, 1983.
ALBUQUERQUE, R.L . Contribuição ao estudo químico de plantas medicinais do Brasil: Plectranthus barbatus Andr. Plectranthus amboinicus (Lour)Spreng. 2000. 166p. Dissertação (Mestrado em Química Orgânica) Universidade Federal do Ceará, Fortaleza.
ALMEIDA, F.C.G.; LEMONICA, I.P. The toxic effects of Coleus barbatus B. on the different periods of pregnancy in rats. Journal of Ethnopharmacology, v.73, p.53-60, 2000.
BAETA, E.C. M. A. et al. Variação sazonal de componentes químicos em algumas plantas medicinais Lamiaceae. Revista Brasileira de Farmacologia, v.78, n.2, p.31-2, 1997.
BHAKUNI, D.S.; DHAWAN, B.N.; MEHROTRA, B.N. Dhar Sreening of Indian plants for biological activity: part III. Indian Journal of Experimantal Biology, v.9, p.91-102, 1970.
BHAT, S.V. et al. Structures and stereochemistry of new labdane diterpeneoids from Coleus forskohlii Brinq. Tetrahedron Letters, v.19, p.1669-72, 1977.
BHAT, S.V. et al. The antihypertensive and positive inotropic diterpene forskolin: effects of strutural modifications on its activity. Journal Medicinal Chemistry, v.26, p.486-92, 1983.
BRISTOW, M.R. et al. Pharmacology and inotropic potential of forskolin in human heart. Journal of Clinical Investigation, v.74, p.212-23, 1984.
BURKA, J.F. Effects of selected bronchodilators on antigen - and A23187 - induced contraction of Guinea-pig traquea. The Journal Pharmacology and Experimental Therapeutics, v.225, n.2, p.427-35, 1983.
CARRICONDE, C. et al. Plantas medicinais & plantas alimentícias. Recife: Universidade Federal Rural de Pernambuco, 1996. 153p.
CASTRO, M.A.S. et al. Efeitos antinociceptivo e antiinflamatório do extrato aquoso (EA) de duas variantes morfológicas de Plectranthus barbatus (boldo brasileiro). In: SIMPÓSIO DE PLANTAS MEDICINAIS DO BRASIL, 15., 1998, Água de Lindóia. Resumos ... São Paulo, 1998. 145p.
CHALCHAT, J.C.; GARRY, R.; MUHAYIMANA, A. Plantas aromáticas de Ruanda. Composição química de duas Labiaceae, Plectranthus barbatus e Plectranthus sylvestris. Revista Italiana Delle Essenze, Dei Profumi e Delle Piante Officinale, v.7, p.665-74, 1996.
COSTA, M.C.C.D. Aspectos farmacológicos de Plectranthus barbatus Andr. (Lamiaceae): atividades antimicrobiana, citotóxica e antitumoral. 2002. 124p. Tese (Doutorado em Ciências Biológicas)-Universidade Federal de Pernambuco, Recife.
COSTA, M.C.C.D. Atividade citotóxica de Plectranthus barbatus Andr. (Lamiaceae). Acta Farmacêutica Bonaerense, v.22, n.2, p.155-8, 2003.
DUBEY, M. P . et al. Pharmacological studies on coleonol, a hypotensive diterpene from Coleus forskohlii. Journal of Ethnopharmacology, v.3, p.1-13, 1981.
FISCHMAN, L.A. et al. The water extract of Coleus barbatus Benth. decreases gastric secretion in rats. Memoria Instituto Oswaldo Cruz, n.86, supl. 11, p.141-3, 1991.
KASONIA, K. Estudos preliminares de extratos de plantas usados na patologia respiratória em Kivu/Zaire sobre isolados de anéis da traquéia de porcos da Índia. Belgian Journal of Botany, v.128, n.2, p.165-75, 1995.
KELECOM, A. Isolation, structure determination, and absolute configuration of barbatusol, a new bioatctive diterpene with a rearranged abietane skeleton from the labiate Coleus barbatus. Tetrahedron, v.39, n.21, p.3603-8, 1983.
KELECOM, A.; SANTOS, T.C.; MEDEIROS, W.L.B. Secoabietane diterpenes from Coleus barbatus . Phytochemistry, v.26, n.8, p.2337-40, 1987.
KERNTOPE, M.R. Contribuição ao conhecimento químico de plantas medicinais cultivadas no Nordeste do Brasil: Plectranthus barbatus Andr. (syn. Coleus barbatus Benth.). 1998. 200p. Dissertação (Mestrado em Química Orgânica) - Universidade Federal do Ceará, Fortaleza.
KROMBHOLZ, R. et al. Production of forskolin by axenic Coleus forskohlii roosts cultivated in shake flasks and 20-l glass jar bioreactors. Planta Medica, v.58, p.328-33, 1992.
LINDNER, E.; DOHADWALLA, A.N.; BHATTACHARYA, B.K. Positive Inotropic and blood pressure lowering activity of a diterpene derivative: isolated from Coleus forskohlii : forskolin. Arzneimittel-Forschung, v.28, p.284-89, 1978.
MATU, E.N.; STADEN V.J. Antibacterial and anti-inflammatory activities of some plants used for medicinal purposes in Kenya. Journal of Ethnopharmacology, v.87, p.35-41, 2003.
MUHAYIMANA, A.; CHALCHAT, J.C.; RAYMOND-PHILIPPE, G. Composição química dos óleos essenciais de algumas plantas medicinais de Ruanda. Journal of Essential Oil Research, v.10, n.3 p.251- 9, 1998.
RODRIGUES, P. A. Escola Paulista de Medicina/ SP . In: SIMPÓSIO DE PLANTAS MEDICINAIS DO BRASIL, 12., 1992, Curitiba. Anais... Curitiba, 1992. p.58.
ROY, R. et al. Minor diterpenes from Coleus forskohlii. Phytochemistry, v.34, p.1577-80, 1993.
SCHULTZE, C. et al. Mecanismos da ação anti-secretora ácida gástrica do extrato aquoso e de frações isoladas de Plectranthus barbatus (Andrews) Benth. In: SIMPÓSIO DE PLANTAS MEDICINAIS DO BRASIL, 16., 2000, Recife. Anais...Recife, 2000. 224p.
SEN, J. et al. Production of forskolin in vitro cultures of Coleus forskohlii. Planta Medica, v.58, p.324-7, 1992.
SOUZA, W.M.A; MAIA, M.B.S. Estudo da toxicidade subcrônica do Plectranthus barbatus a partir do levantamento etnofarmacológico de plantas medicinais no município de Tacaratu/PE. 2000, 49p. (Monografia) - Universidade Federal de Pernambuco, Recife.
TANDON, J.S. et al. Structure of coleonol, a biologically active diterpene from Coleus forskohlii. Indian Journal of Chemistry, v.15, p.880-3, 1977.
TANDON, J.S. Crocetin-dialdehyde from Coleus forskohlii Briq., Labiatae. Helvetica Chimica Acta, v. 62, p.2706-7, 1979.
VALDÉS, L.J.; MISLANKAR, S.G.; PAUL, A.G. Coleus barbatus (C. forskohlii) (Lamiaceae) and the Potencial New Drugs Forskolin (Coleonol). Economic Botany, v.41, n.4, p.474-83, 1987.
ZELNIK, R. et al. Barbatusin and cyclobutatusin, two novel diterpenoids from Coleus barbatus Bentham. Tetrahedron, v.33, p.1457-67, 1977.
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