Effect of Petiveria alliacea L. on intestinal secretion and motility in rodents
DOI:
https://doi.org/10.70151/m1ntrj02Keywords:
Petiveria alliacea L., tipi, antispasmodic, medicinal plantsAbstract
This article investigated the action of ethanolic extract (EE), aqueous (AF) and chloroformic (CF) fractions of Petiveria alliacea L. (tipi)'s leaves in the intestinal secretion and motility of rodents. The local population uses this plant as antispasmodic. The EE's phytochemistry tests revealed the presence of steroids, coumarins and tannins. In the pharmacological tests, the EE (0.25 or 0.5 g/kg), by oral administration (p.o.), reduced the intestinal secretion induced by castor oil, in 24.1 and 14.4%, respectively. The intestinal transit was reduced by EE 0.5, 1.0 or 4.0 g/kg (p.o.), in 17.6; 31.5 and 29.4%, respectively. In preparations of the isolated rat (Rattus norvegicus) jejunum, acetylcholine (ACh) cumulative concentration-effect curves, in the presence of the EE (2.0 or 4.0 mg/mL), were displaced to right in 2.7 and 5.6 times. Concentrations of 0.5; 2.0 or 4.0 mg/mL of EE reduced the maximum effect by 13.9; 32.1 and 47.3%, respectively. The CF (1.0 mg/mL) displaced the ACh cumulative curves to the right in 2.5 times. These results suggest that the leaves of Petiveria alliacea L. possess active substances that can inhibit the intestinal secretion and motility.
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