Evaluation of the genotoxic and antigenotoxic activity of Euphorbia tirucalli (Aveloz)

Authors

DOI:

https://doi.org/10.70151/6fz9qy13

Keywords:

Euphorbia tirucalli, latex, genotoxic, antigenotoxic

Abstract

The use of medicinal plants, including extracts, of popular use as a therapeutic resource is a widespread trend in the Brazilian population. Euphorbia tirucalli is widely used by Brazilian popular medicine in the treatment of lesions, infectious diseases, tumors and inflammatory diseases. This is study aimed to evaluate the genotoxic and antigenotoxic activity of E. tirucalli (aveloz). Latex was obtained from a plant specimen, in the city of Goiânia, and diluted to the concentration of 1 mg/ml. In order to evaluate the genotoxic and antigenotoxic activity of the aqueous solution of E. tirucalli latex were performed by the micronucleus test in the hematopoietic bone marrow of mice. The cytogenetic analysis of the slides was performed in order to detect possible chromosomal changes and / or losses (micronuclei) in the polychromatic erythrocytes of the bone marrow of the animals submitted to the different treatments. The results showed that in the treatments concomitant with the aqueous solutions of latex of E. tirucalli and mitomycin C, there was a decrease in micronuclei numbers in 2000 EPC. Our results allowed to conclude that the aqueous solutions of E. tirucalli latex presented genotoxic, antigenotoxic, cytotoxic and anticitotoxic activity and the concomitant use of the aqueous solutions of the latex of E. tirucalli and mitomycin C was not indicated, as the genotoxic and cytotoxic effects of MMC were decreased And thus not achieving the expected effect of this highly genotoxic agent.

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Author Biographies

  • Rodrigo Ansaloni de Oliveira, Pontifícia Universidade Católica de Goiás

    Laboratório de Estudos Experimentais e Biotecnológicos

  • Fátima Mrué, Pontifícia Universidade Católica de Goiás

    Laboratório de Estudos Experimentais e Biotecnológicos

  • Lucas Rodrigues Sampaio, Pontifícia Universidade Católica de Goiás

    Laboratório de Estudos Experimentais e Biotecnológicos

  • Maria Alice Montes de Sousa, Pontifícia Universidade Católica de Goiás

    Laboratório de Estudos Experimentais e Biotecnológicos

  • Lilian Alves Araújo, Pontifícia Universidade Católica de Goiás

    Laboratório de Estudos Experimentais e Biotecnológicos

  • Paulo Roberto de Melo Reis, Pontifícia Universidade Católica de Goiás

    Laboratório de Estudos Experimentais e Biotecnológicos

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Published

2024-09-18

Issue

Vol. 22 No. 1 (2020)

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Articles

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How to Cite

Evaluation of the genotoxic and antigenotoxic activity of Euphorbia tirucalli (Aveloz). (2024). Revista Brasileira De Plantas Medicinais Brazilian Journal of Medicinal Plants, 22(1), 1-7. https://doi.org/10.70151/6fz9qy13