A review of antifertility folkloric plants tested in laboratory animals

Authors

  • D. C. Damasceno Faculdade de Medicina de Marília
  • G. T. Volpato Universidade Estadual Paulista
  • I. P. Lemonica Universidade Estadual Paulista

DOI:

https://doi.org/10.70151/g4zzww16

Keywords:

medicinal herbs, plant, fertility, anti-fertility, hormones, animals

Abstract

A review of anti-fertility native folklore plants in laboratory animals. The use of natural active principals is widespread among a great proportion of the rural population, or by people who do not have easy access to medical assistance. These active principles are used as food or medicines, and even for purposes of contraception. It becomes necessary to establish a relationship between the folklore habits and current information on the nature of anti-fertility substances, and knowledge of their mechanisms. Anti-fertility agents may exert their actions in a number of areas, (hypothalamus, anterior pituitary, oviduct, uterus, and vagina), inhibiting synthesis and/or liberation of hormones (follicle-stimulating, luteinizing, and steroid hormones), ovulation, ovum transportation, and implantation process. Therefore, a review of literature was carried out, including of several plants used by women as abortifacient and anti-fertility agents to compare their effects with those obtained among laboratory animals.

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Author Biographies

  • D. C. Damasceno, Faculdade de Medicina de Marília

    Faculdade de Medicina de Botucatu

    Departamento de Ginecologia e Obstetrícia

  • G. T. Volpato, Universidade Estadual Paulista

    Faculdade de Medicina de Botucatu

    Departamento de Ginecologia e Obstetrícia

  • I. P. Lemonica, Universidade Estadual Paulista

    Departamento de Farmacologia

References

Al-Dissi, N.M.; Salhab, A.S.; Al-Hajj, H.A. Effects of Inula viscosa leaf extracts on abortion and implantation in rats. Journal of Ethnopharmacology, v.77, p.117-121, 2001.

Al-Kamis, K.I., Al-Said, M.S., Islam, M.W., Tariq, M., Parmar, N.S., Ageel, A.M. Antifertility, anti-implantation and abortifacient activity of the aqueous extract of Cuminum cyminum. Fitoterapia, v.59, p.5-10, 1988.

Almeida, F.G.C.; Lemonica, I.P. The toxic effect of Coleus barbatus B. on the different periods of pregnancy in rats. Journal of Ethnopharmacology, v.73, p.53-60, 2000.

Al-Said, M.S., Al-Kamis, K.I., Islam, M.W., Parmar, N.S., Tariq, M., Ageel, A.M. Post-coital antifertility activity of the seeds of Coriandrum sativum in rats. Journal of Ethnopharmacology, v.21, p. 165-173, 1987.

Batta, S.K., Santhakumari, G. The antifertility effect of Ocimum sanctum and Hibiscus rosa sinensis. Indian Journal of Medical Research, v.59, p.777-781, 1971.

Bhatnagar, U. Post-coital contraceptive effects of an alcoholic extracts of the Daucus carota Linn. seed in rats. Clinical Drug Investigation, v.9, p.30-36, 1995.

Boling, J.L., Blandau, R.J. Egg transport through the ampullae of the oviducts of rabbits under various experimental conditions. Biology of Reproduction, v.4, p.174-184, 1971.

Choudhuri, D., Adhikary, P., Banerji, J., Jana, S., Chatterjee, A. Pregnancy interceptive effect of Piper betle. Fitoterapia, v.58, p.397-401, 1990.

Claeson. U.P.; Malmfors, T.; Wikman, G.; Bruhn, J.G. Adhatoda vasica: a critical review of ethnopharmacological and toxicological data. Journal of Ethnopharmacology, v.72, p.1-20.. 2000.

Dafni, A.; Yaniv, Z.; Pelevich, D. Ethnobotanical survey of medicinal plants in Northen Israel. Journal of Ethnopharmacology, v. 10, p.295-310, 1984.

Damasceno, D.C., Lemonica, I.P. Embryotoxicity and anti-implantation effects of rosemary (Rosmarinus officinalis L.) extract in pregnant rats within preimplantation period. Revista Brasileira de Toxicologia, v. 12, p.47-54, 1999.

Dhanasekaran, S., Suresh, B., Sethuraman, M., Rajan, S., Dubey, R. Antifertility activy of Ailanthus excelsa Linn. In female albino rats. Indian Journal of Experimental Biology, v.31, p.384-385, 1993.

Di Stasi, L.C., Santos, E.M.G., Santos, C.M., Hiruma, C.A. Plantas Medicinais na Amazônia. São Paulo: Editora Unesp, 1989.

Farnsworth, R.N., Bingel, A.S., Cordell, G.A., Crane, F.A., Fong, H.H.S. Potencial value of plants as source of nem antifertility agents. Journal of Pharmacological Science, v.64, p.535-598, 1975.

Gardner, D.R., Panter, K.E., James, L.F., Stegelmeier, B.L. Abortifacient effects of lodgepole pine (Pinus contorta) and common juniper (Juniperus communis) on cattle. Veterinary and Human Toxicology, v.40, p.260-263, 1998.

Garg, S.K., Garg, G.P. Antifertility effect of oil from few indigenous plants on female albino rats. Indian Journal of Medical Research, v.59, p.302, 1970.

Garg, S.K. Antifertility effect of oil from few indigenous plants on female albino rats. Planta Medica, v.26, p.391-393, 1974.

Goonasekera, M.M., Gunawardana, V.K., Jayasena, K., Mohammed, S.G., Balasubramaniam, S. Pregnancy terminating effect of Jatropha curcas in rats. Journal of Ethnopharmacology, v.47, p.117-123, 1995.

Guerra, M.O., Peters, V.M. Screening for reproduct toxicity in rats of a decoction of Himathanthus sucuuba stem bark. Journal of Ethnopharmacology, v.34, p.195-199, 1991.

Guyton, A.C., Hall, J.E. Tratado de Fisiologia Médica. Rio de Janeiro: Guanabara-Koogan, 1997.

Hiremath, S.P.; Rudresh, K.; Badami, S; Patil, S.B.; Patil, S.R. Post-coital activity of Acalypha indica L. Journal of Ethnopharmacology, v.67, p.253-258, 1999.

Keshri, G., Singh, M.M., Lakshmi, V., Kamboj, V.P. Post-coital contraceptive efficacy of the seeds of Nigella sativa in rats. Indian Journal of Physiology and Pharmacology, v.39, p.59-62, 1995.

Kholkute, S.D., Munshi, S.R. Antifertility activity of indigenous plants Sida carpinifolia and Podocarpus brevifolius Stapf in female rats. Indian Journal of Experimental Biology, v.16, p.696-698, 1978.

Langeloh, A., Maidana-Leguizamon, F., Dalsenter, P. Potencial abortivo e infertilizante de plantas brasileiras contaminantes ocasionais de pastagens de bovinos e outros herbívoros de interesse económico. Pesquisa Veterinária Brasileira, v. 12, p.11-18, 1991.

Lemonica, I.P., Macedo, A.M.R.B. Abortive and/or embryototoxic effect of Cinnamomum zeylanicum leaf. Fitoterapia, v.65, p.431-434, 1994.

Lemonica, I.P., Damasceno, D.C., Di Stasi, L.C. Study of the embryotoxic effects of an extract of rosemary (Rosmarinus officinalis L.). Brazilian Journal of Medical and Biological Research, v.29, p.223-227, 1996.

Luna Costa, A.M.; Silva, J.C.; Campos, A.R.; Rao, V.S.; Maciel, M.A.; Pinto, A.C. Antioestrogenic effect of trans-dehydrocrotonin, a nor-clerodane diterpene from Croton cajucara Benth. in rats. Phytotherapy Research, v, 13, p.689-691, 1999.

Lutterodt, G.D. Abortifacient properties of an extract from Sida veronicaefolia. Journal of Ethnopharmacology, v.23, p.27-37, 1988.

Marona, H.R.N., Langeloh, A., Schenkel, E.P. Atividade abortiva de Ateleia glazioviana (Leg. Papilionoideae) em ratas. Pesquisa Veterinária Brasileira, v. 12, p.81-83, 1992.

Mats, M.N., Bogatkna, V.F., Vishnyakov-Yu, S. Contraceptive activity of an extract from Ambrosia artemisiifolia. Rastitel Research, v.23, p. 125-129, 1987.

Mazumder, U.K., Gupta, M., Pramanik, G., Mukhopadhyay, R.K., Sarkar, S. Antifertility activity of Nelumbo nucifera in mice. Indian Journal of Experimental Biology, v.30, p.533-534, 1992.

Mishra, A., Dogra, J.V.V., Singh, J.N., Jha, O.P. Post-coital antifertility activity of Annona squamosa and Ipomoea fistulosa. Planta Medica, v.35, p.283-285, 1979.

Morris, J.M., Van Wagenen, G. Interception: The use of postovulatory estrogens to prevent implantation. American Journal of Obstetrics and Gynecology, v.115, p. 101-116, 1973.

Mukherjee, S., Talwar, G.P. Early post implantation contraceptive effects of a purified fraction of neem (Azadirachta indica) seeds, given orally in rats: communis. Fitoterapia, v.65, p.248-252, 1994.

Nath, D., Sethi, N., Srivastava, S., Jain, A.K. Teratogenic evaluation of a indigenous antifertility medicinal plant Gossypium herbaceum in rat. Fitoterapia, v.68, p. 137-139, 1997.

Nishimura, H., Tanimura, T. Clinical Aspects of the Teratogenicity of Drugs. New York: American Elsevier Publishing Company, 1976.

Nwobodo, E.O., Nwafia, W.C., Ezeigbo, J.C.. Onwughalu, J. The post-coital contraceptive activity of Sida linifolia. Fitoterapia, v.67, p.291-293, 1996.

Offiah, V.N., Anyanwu, I.I. Abortifacient activity of an aqueous extract of Spondias mombin leaves. Journal of Ethnopharmacology, v.26, p.317-320, 1989.

Okwuasaba, F.K., Osunkwo, U.A., Ekpenyong, K.I.. Onwukeme, K.E., Olaynka, A.O., Uguru, M.Ο., Das, S.C. Anticonceptive and estrogenic effects of a seed extract of Ricinus communis var. minor. Journal of Ethnopharmacology, 34: 141-145. (1991).

Pakrashi, A., Pakrasi, P. Antifertility efficacy of the plant Aristilochia indica Linn, on mouse. Contraception, v.20, p.49-54, 1979.

Pakrashi, A., Bhattacharya, K., Kabir, S.N., Pal, A.K. Flowers of Hibiscus rosea-sinensis, a potential source of contragestive agent III: Interceptive effect of benzene extract in mouse. Contraception, v.34, p.523-536, 1986.

Piyachaturawat, P., Glinsukon, T., Chanjarunee, A. Antifertility effect of Citrus hystrix. Journal of Ethnopharmacology, v.13, p.105-110, 1985.

Planas, G.M., Kuc, J. Contraceptive properties of Stevia rebaudiana. Science, v. 162, p.1007, 1968.

Prakash, A.O., Saxena, V., Shukla, S., Tewari, R.K.. Mathur, S., Gupta, A., Sharma, S., Mathur, R. Anti-implantation activity of some indigenous plants in rats. Acta of European Fertility, v. 16, p.441-448, 1985.

Prakash, A.O., Sisodia, B., Mathur, R. Biological profile of butanolic extract of dried fruits of Juniperus communis. Fitoterapia v.85, p. 248-252, 1994.

Ramos, R.R., Alarcon-Aguilar, F., Lara-Lemus, L., Flores-Saenz, I.L. Hypoglycemic effect of plants used in Mexico as antidiabetics. Archieve of Medical Research, v.23, p.59-64, 1992.

Rao, M.V.; Alice, K. M. Contraceptive effects of Phillanthus amarus in female mice. Phytotherapy Research, v.15, p.265-267, 2001.

Rao, V.S.N., Menezes, M.A.S., Gadelha, M.G.T. Antifertility screening of some indegenous plants of Brazil. Fitoterapia, v.59, p.17-20, 1988.

Sanyal, S. Acta Endocrinologica, v.28 (Suppl), p.72-78, 1956.

Sethi, N., Nath, D., Singh, R.K., Srivastava, R.D. Antifertility and teratogenic activity of Cannabis sativa in rats. Fitoterapia, v.62, p.69-71, 1991.

Sethi, N., Nath, D., Singh, R.K., Srivastava, R.K. Antifertility and teratogenic activity of some indigenous medicinal plants in rats. Fitoterapia, v.61, p.64-67, 1989.

Shivalingappa, H.;; Satyanarayan, N.D.; Purohit, M.G. Antiimplantation and pregnancy interruption efficacy of Rivea hypocrateriformis in the rat. Journal of Ethnopharmacology, v.74, p.245-249, 2001.

Singh, M.M., Chowdhury, S.R., Kulshreshtha, D.K., Kamboj, V.P. Antigestagenic activity of Ixora finlayconiana in rats. Contraception, v.48, p.178-191, 1993.

Vessal, M., Mehrani, H.Á., Omrani, G.H. Effects of an aqueous extract of Physalis alkekengi fruit on estrus cycle, reproduction and uterine creatine kinase BB-isozyme in rats. Journal of Ethnopharmacology, v.34, p.69-78, 1991.

Weniger, B. Plants of Haiti used as antifertility agents. Journal of Ethnopharmacology, v.6, p.67-84, 1982.

Yadav, R.; Jain, G.C. Antifertility effect os aqueous extract of seeds of Cassia fistula in female rats. Advances in Contraception, v.15, p.293-301, 1999.

Zia-Ul-Haque, A., Qazi, M.H., Hamdard, M.E. Studies on the antifertility properties of active components isolated from the seeds of Abrus precatorius. Pakistan Journal of Zoology, v.15, p.144-146, 1983.

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Published

2002-06-13

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Review

How to Cite

A review of antifertility folkloric plants tested in laboratory animals. (2002). Revista Brasileira De Plantas Medicinais, 5(1), 19-26. https://doi.org/10.70151/g4zzww16