Gastroprotectíve action of the extract of Solanum lycocarpum St, Hil, leaves (Lobeira)
DOI:
https://doi.org/10.70151/xnv34h43Keywords:
Solanum lycocarpum, anti-ulcer agents, plant physiology, plant leaves, medicinal plantsAbstract
This paper aimed to study the gastro-protective activity and the mechanism of action of the ethanol extract of S. lycocarpum St. Hil. leaves (ExtOH) on gastric mucus. In rats, previously treated for 1 hour with ExtOH (1 and 2 g/kg p.o.), the index of gastric ulceration in an indomethacin-induced ulcers model (30 mg/kg, s.c., 3 h), was reduced from 38.3 ± 11.0 to 13.8 ± 2.7 and 8.6 ± 3.6, respectively. To evaluate whether this gastro-protective activity was related to the classic cholinergic mechanism of gastric secretion, frog gastric mucose was incubated in the chamber of Ussing. In this condition the basal secretion of H+ was 7.3 ± 0.3 µEq/g/15min, previous incubation with 224 and 448 mg/mL of ExtOH reduced the acid secretion induced by ACh (4 x 10-4 M) from 10.7 ± 0,5 to 7.8 ± 0.4 and 6.3 ± 0.2 µEq/g/15min, respectively. Increased doses of ACh (up to 4 x 10-3 M) did not revert the ExtOH (448 mg/mL) inhibition on gastric secretion. These resulls demonstrated the anti-ulcer and anti- secretionsry gastric effects of the ethanol extract of the Sofenum lycocarpum St. Hil. leaves, probably via a non competitive cholinergic blockade.
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