Ethnopharmacology as a tool for the Selection of Medicinal Plants for Screening Antitumour Activity
DOI:
https://doi.org/10.70151/fd219588Keywords:
ethnopharmacology, ethnobotany, medicinal plants, farmacognosy, databaseAbstract
This study aimed to explore ways of organizing lay information on medicinal plants that would be specifically relevant for the selection of species with potential anticancer activity. For that matter, a combination of concepts and methods from ethnobotany and ethnopharmacology with chemotaxonomy data was used. A databases was constructed with ethnopharmacological informations about plants used for signs and symptoms frequently related to a variety of cancers associated with cancer cell lines available at the South American Anticancer Drug Development Office (SOAD). Toxic effects of known anticancer drugs reported for plants were also considered The databases has 1.430 records of use for 855 plant species. Taking into account the number of records, number of indications, number of species and degree of conformity in usage, the plant families Compositae, Leguminosae, Apocynaceae, Euphorbiaceae and Rubiaceae, contributed with the greater number of potential plant species. In order to optimize the selection, records of these families were combined with the major therapeutic indications. The species that received the highest importance scores were Bidens pilosa, Achyrocline satureoides, Artemisia absinthyum, Ambrosia tenuifolia, Arnica montana, Artemisia vulgaris, Chaptalia nutans, Spilanthes ocymifolia, Cassia alata, Croton antisyphiliticus, Echites peltala, Parahancomia amapa and Retmiphyllum schomburgkii.
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AMOROSO. GÉLY, A Uso de plantas medicinais por caboclos do baixo Amazonas. Barcarena, Pa, Brasil Boletim do Museu Paraense Emílio Goeldi. v 4. n 1. p 47-131. 19S&.
BALICK. M.J The Ethnobotany and the identification of therapeutic agents 1rom the rain forest In. Cl BA FOUNDATION SIMPOSIUM 154. 1990, Chischester. Proceedings Chilchesler: Wiley- Interscience, 1990. p. 22-31.
BRASIL Ministério da Saude . Instituto Nacional do Câncer O problema do câncer no Brasil Rio de Janeiro : INCA/Pro-Onco, . 1997.p. 1-60.
BRASIL Ministério da Saúde . Secretaria Nacional de Assistência à Saúde Estimativa da incidência e mortalidade por câncer no Brasil Rio de Janeiro INCA/Pro-Onco. 1998 p 1-18.
CARLSON. T.J., COOPER. R., KING, S.R., ROZHON. E.J Modern science and traditional healing. Special Publication Royal Society Chemical . n. 200 , p 84-95, 1997.
CORDELL, GA.. BEECHER. C.W W . PEZZUTO. J.M. Can elhnopharmacology contribute to the development of new anticancer drugs9 Journal of Ethnopharmacology, v. 32, p 117- 33. 1991.
CRAGG, G.M E BOYD. M R. Drug discovery and development at the National Cancer Intitule the role of natural products of plant origen. In: BALICK, M., ELISABETSKY, E., LAIRD. S.A. (Eds.) Medicinal resources of the tropical forest biodiversity and its importance to human health. New York : Columbia University Press, 1996 p 101-36.
DI STASI, L.C. Química de produtos naturais: pnncipais constituintes ativos. In:___. Plantas medicinais arte e ciência ; um guia de estudo interdtsciplinar. São Paulo: EDUNESP, 1996. p. 109-27.
DUKE. J. A. Folk anticancer plants containing antitumor compounds In: ETKIN, N.L. (Ed.) Plants in indigenous medicine and diet : biobehavioral approaches- New York Redgrave Pub. 1986. p. 70-90.
ELISABETSKY, E . CASTILHOS. Z.C Plants used as analgesics by amazonian caboclos as a basis for selecting plants for investigation, International Journal of Crude Drug Research , v. 4, p. 309* 20r 1990.
ELISABETSKY, E., SHANLEY, P. Ethnopharmacology in (he Brazilian Amazon. Pharmacology and Therapeutics., v. 64. p. 201-14. 1994 FARNSWORTH. N.R. Screening plants for new medicines. In: Wilson. E.O (Ed.) Biodiversity. Washington National Academy Press. 1989 part 2. chapL 9. p. 83-97.
FARNSWORTH. N.R. The role of elhnopharmacology in drug developmet. In: CIBA FOUNDATION SIMPOSIUM 154, 1990, Chischester. Proceedings Chichester: Wiley-lnterscience, 1990. p. 2-21.
FARNSWORTH. N.R. . KAAS, CJ An approach utilizing information from traditional medicine to identify tumor-inhibiting plants. Journal of Ethnopharmacology, v.3, p.85- 99. 1981.
FRIEDMAN, J. et al. A preliminary classification of the healing potential of medicinal plants, based on a rational analysis of an ethnopharmacological field survey among bedouins in the Negev desert. Israel Journal of Ethnopharmacology v. 16 p. 275-87, 1906.
GOTTLIEB, O R. Elhnopharmacology versus Chemosyslematics in the search for biologically active principles in plants Journal of Ethnopharmacology, v. 6. p 227-38, 1982.
HAMBURGER. M , HOSTETTMANN. K Bioactivity in plants: the link between phytochemistry and medicine Phytochemistry v. 30. n 12. p. 3864- 74. 1991.
HANSEN. S. K. . MILLER. L.L. Regulatory slragegies for the development of adjunctive cancer chemotherapies Drug Information Journal v 31, p. 769-803, 1997.
HARTWELL, J.L. Types of anticancer agents isolated from plants. Cancer Treatment Reports, v. 60. p. 1031-67, 1976. KOELLER, J. The new taxoid—Docetaxel Highlights in Antineoplastic Drugs, v. 12, n. 1, 1994.
MARKMAN. M Cancer drug development: problems and opportunities. Drug Information Journal, v. 32 , p. 1-5, 1998.
SAMUELSSON, G. Nature as a source of new drugs Acta Pharmaceutics Nórdica v. 1. n. 3. p 111-6. 1909.
SANTOS, M.A.C. Potencial anticancerigeno da flora medicinal: definição de estratégias para seleção de espécies Porto Alegre. 1998 185p. Dissertação (Mestrado em Botânica)- Instituto de Biociências. Universidade Federal do Rio Grande do Sul SCHWARTSMANN, G. EORTC strategies for anticancer drug discovery Forum, v. 2. n 5. p 520- 8. 1992.
SÉVENET, T. Looking for new drugs: what criteria9 Journal of Ethnopharmacology, v. 32. p 83-90, 1991.
SOUSA. M P., MATOS. M.E.O., MATOS. F J A . MACHADO, M I.L-, CRAVEIRO. A A Constituintes químicos ativos de plantas medicinais brasileiras Fortaleza Ed Da UFC. 1991. p. 363-7.
SOUZA BRITO, A.R.M., SOUZA BRITO, A.A. Forty years of Brazilian medicinal plant research Journal of Elhnopharmacology. v. 39. p. 53-67, 1993.
SPJUT, R.W . PERDUE. R E Jr Plant folklore: a tool for predicting sources of antitumor activity?. Cancer Treatment Reports, v. 60, p. 979-85, 1976.
TROTTER, R.T. Ethnography and bioassay combined methods for a preliminar screen of home remedies for potential pharmacological activity. Journal of Ethnopharmacology, v 8. p. 113-9, 1983.
TYLER, V.E. Performance and immune deficiencies In:___ Herbs of choice: the therapeutic use of phytomedicinals. New York : Pharmaceutical Procucts Press. 1994 p 171-86.
UNANDER, D.W., WEBSTER, G.L. AND BLUMBERG, B.S. Uses and biossays in Phyllanlhus (Euphorbiaceae). IV. Clustenng of antiviral usesand other effects. Journal of Ethnopharmacology, v. 45. p. 1-18, 1995.
WALL, M E., WANI. M.C. Camptothecin and taxol: from discovery to clinic. Journal Ethnopharmacology, v. 51, p. 239-54, 1996.
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