Benefits of Hibiscus sabdariffa treatment for obesity, associated diseases, and their adverse effects
DOI:
https://doi.org/10.70151/zra53r95Keywords:
Hibiscus sabdariffa, herbal medicines, obesity, adverse reactionAbstract
Obesity is a chronic metabolic disease caused by an imbalance in food intake and energy expenditure, being associated with an increase in adipogenesis. Hibiscus sabdariffa, considered the second most studied plant after green tea, is used against inflammation, obesity, dyslipidemia, hypertension and liver disease. This study aimed to investigate the effects of H. sabdariffa in the treatment of these pathologies and adverse reactions. In vitro studies indicate that H. sabdariffa, administered at a concentration of 2.5 mg/ml, had anti-lipase and anti-amylase activity. In another study, 450 mg of H. sabdariffa extract, administered 3 times a day for 12 weeks, demonstrated a reduction in body weight in women. In one investigation, the same extract lowered blood cholesterol in teenagers when administered at a concentration of 2 g per day for 30 days. In another study, there was an adverse reaction interfering with spermatogenesis in male rats, impairing their fertility. H. sabdariffa had beneficial effects for the adjunctive treatment of obesity and associated diseases, but further clinical trials on the safety and efficacy of this plant are needed.
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Abdallah EM (2016) Antibacterial efficiency of the Sudanese Roselle (Hibiscus sabdariffa L.), a famous beverage from Sudanese folk. Med Ethnopharmacol 5:186-191.
Alarcon-Aguilar FJ, Zamilpa A, Perez-Garcia MD, Almanza-Perez JC, Romero-Nuñez E, Camppos-Sepulveda EA, Vazquez-Carrillo LI, Roman-Ramos R (2007) Effect of Hibiscus sabdariffa on obesity in MSG mice. J Ethnopharmacol 114:66-71.
Ajiboye TO, Raji HO, Adeleye AO, Adigun NS, Giwa OB, Ojewuyi OB, Oladiji AT (2016) Hibiscus sabdariffa calyx palliates insulin resistance, hyperglycemia, dyslipidemia andoxidative rout in fructose-induced metabolic syndrome rats. J Sci Food Agric 96:1522–1531.
Arruda A, Cardoso CA, Vieira Mdo C, Arena AC (2016) Safety assessment of Hibiscus sabdariffa after maternal exposure on male reproductive parameters in rats. Drug Chem Toxicol 39:22-27. https://www.doi.org/10.3109/01480545.2014.1003938
Arteaga EVV, Mendieta EC, Solís HE, Aguirre AAC, Gastélum FJG, Díaz JCM, González JAR, Márquez-Aguirre AL (2013) Hibiscus sabdariffa L. aqueous extract attenuates hepatic steatosis through down-regulation of PPAR-g and SREBP-1c in diet-induced obese mice. Food Funct 618-626.
Ayerdi SG, Mateos R, Basurto RI, Largo C, Serrano J, Serrano AB, Sarriá B, Bravo L, Tabernero M (2014) Effects of consuming diets containing Agave tequilana dietary fibre
and jamaica calyces on body weight gain and redox status in hypercholesterolemic rats. Food Chem 148:54-59.
Buchholz T, Melzig MF (2016) Medicinal plants traditionally used for treatment of obesity and diabetes mellitus – screening for pancreatic lipase and α-amylase inhibition. Phytother Res 30:260-266.
Chang HC, Peng CH, Yeh DM, Kao ES, Wang CJ (2013) Hibiscus sabdariffa extract inhibits obesity and fat accumulation, and improves liver steatosis in humans. Food Funct 5:734-739.
Díaz CM, López PM, Enríquez S, Sanromán R, González I, Leyva JF (2010) Effects of Hibiscus sabdariffa extract powder and preventive treatment (diet) on the lipid profiles of patients with metabolic syndrome (MeSy). Phytomedicine. 17:500-505.
Dickel ML, Rates SM, Ritter MR (2007) Plants popularly used for loosing weight purposes in Porto Alegre, South Brazil. J Ethnopharmacol 109:60-71.
Fakeye T (2008) Toxicity and immunomodulatory activity of fractions of Hibiscus sabdariffa Linn. (Family Malvaceae) in animal models. J Tradit Complement Med 5:394-398.
Fakeye TO, Pal A, Bawankule DU, Yadav NP, Khanuja SP (2009) Toxic effects of oral administration of extracts of dried calyx of Hibiscus sabdariffa Linn. (Malvaceae). Phytother Res 23:412-416.
Fassina P, Scherer Adami F, Terezinha Zani V, Kasper Machado IC, Garavaglia J, Quevedo Grave MT, Ramos R, Morelo Dal Bosco S (2015) The effect of Garcinia cambogia as coadjuvant in the weight loss process. Nutr Hosp 32:2400-2408.
Frank T, Netzel G, Kammerer DR, Carle R, Kler A, Kriesl E, Bitsch I, Bitsch R, Netzel M (2012) Consumption of Hibiscus sabdariffa L. aqueous extract and its impact on systemic antioxidant potential in healthy subjects. J Sci Food Agric 92:2207-2218.
Gamboa-Gómez CI, Rocha-Guzmán NE, Gallegos-Infante JA, Moreno-Jiménez MR, Vázquez-Cabral BD, González-Laredo RF (2015) Plants with potential use on obesity use on obesity and its. Excli J 14:809-831.
Huang TW, Chang CL, Kao ES, Lin JH (2015) Effect of Hibiscus sabdariffa extract on high fat diet induced obesity and liver damage in hamsters. Food Nutr Res 59:18-29.
Huang CC, Tung YT, Huang WC, Chen YM, Hsu YJ, Hsu MC (2016) Beneficial effects of cocoa, coffee, green tea, and garcinia complex supplement on diet induced obesity in rats. BMC Complement Altern Med 100:1077-1086.
Iyare EE, Adegoke OA (2008) Mechanism of the delayed puberty onset in offspring of rats that consumed aqueous extract of Hibiscus sabdariffa during pregnancy Niger J Physiol Sci 23:71-77.
Kao ES, Yang MY, Hung CH, Huang CN, Wang CJ (2016) Polyphenolic extract from Hibiscus sabdariffa reduces body fat by inhibiting hepatic lipogenesis and preadipocyte adipogenesis. Food Funct 16:82-172.
Kim JK, So H, Youn MJ, Kim HJ, Kim Y, Park C, Kim SJ, Ha YA, Chai KY, Kim SM, Kim KY, Park R (2007) Hibiscus sabdariffa L. water extract inhibits the adipocyte differentiation through the PI3-K and MAPK pathway. J Ethnopharmacol 114:260-267.
Khosravi H, Khanabadi BA, Ardekani M, Fatehi F (2009) Effects of sour tea (Hibiscus sabdariffa) on lipid profile and lipoproteins in patients with type II diabetes. J Altern Complement Med 15:899-903.
Khosravi H, Ahadi Z, Barzegar K (2013) The rffect of green tea and sour tea on blood pressure of patients with type 2 diabetes: a randomized clinical trial. J Diet Suppl 10:105-115.
Lee CH, Kuo CY, Wang CJ, Wang CP, Lee YR, Hung CN, Lee HJ (2012) A polyphenol extract of Hibiscus sabdariffa L. ameliorates acetaminophen-induced hepatic steatosis by attenuating the mitochondrial dysfunction in vivo and in vitro. Biosci Biotechnol Biochem 76:646-651.
Lin HH, Chen JH, Wang CJ (2011) Chemopreventive Properties and Molecular Mechanisms of the Bioactive Compounds in Hibiscus sabdariffa Linne. Curr Med Chem 18:1245-1254.
Maeda H (2015) Nutraceutical effects of fucoxanthin for obesity and diabetes therapy: review. J Oleo Sci 64:125-132.
Mohagheghi A, Maghsoud S, Khashayar P, Ghazi-Khansari M (2011) The effect of Hibiscus sabdariffa on lipid profile, creatinine, and serum electrolytes: a randomized clinical trial. Gastroenterol 1-4. https://www.doi.org/10.5402/2011/976019
Mahomoud IY (2012) Effect of extract of Hibiscus on the ultrastructure of the testis in adult mice. Acta Histochem 114:342-348.
Rocha IC, Bonnlaender B, Sievers H, Pischel I, Heinrich M (2012) Hibiscus sabdariffa L. – a phytochemical and pharmacological review. Food Chem 165:424-443.
Sabzghabaee AM, Ataei E, Kelishadi R, Ghannadi A, Soltani R, Badri S, Shirani S (2013) Effect of Hibiscus sabdariffa calices on dyslipidemia in obese sdolescents: a triple-masked randomized controlled. Mater Sociomed 25:76-79.
Sireeratawong S, Itharat A, Khonsung P, Lertprasertsuke N, Jaijoy K (2013) Toxicity studies of the water extract from the calyces of Hibiscus sabdariffa L. in rats. J Tradit Complement Altern Med 10:122-127.
Su HM, Feng LN, Zheng XD, Chen W (2016) Myricetin protects against diet-induced obesity and ameliorates oxidative stress in C57BL/6 mice. J Zhejiang Univ Sci B 17:437-446.
Wang J, Cao X, Jiang H, Qi Y, Chin KL, Yue Y (2014) Antioxidant activity of leaf extracts from different Hibiscus sabdariffa accessions and simultaneous determination five major antioxidant compounds by LC-Q-TOF-MS. Molecules 19:228-236.
Yang MY, Peng CH, Chan KC, Yang YS, Huang CN, Wang CJ (2010) The hypolipidemic effect of Hibiscus sabdariffa polyphenols via inhibiting lipogenesis and promoting hepatic lipid clearance. Food Chem 58:850-859.
Zarrabal CO, Jones HPM, Flores OZ, Hipólito NC, Dermitz BDM, Uscanga AMG, Hernández PMF (2009) Effect of Hibiscus sabdariffa L. dried calyx ethanol extract on fat absorption-excretion, and body weight implication in rats. Biomed Biotechnol 10:1155-1160.
Zhen J, Villani TS, Guo Y, Qi Y, Chin K, Pan MH, Ho CT, Simon JE, Wu Q (2016) Phytochemistry, antioxidant capacity, total phenolic content and anti-inflammatory activity of Hibiscus sabdariffa leaves. Food Chem 19:673-680.
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