Phytochemical profile, traditional uses, and biological activities of Duguetia furfuracea: A review

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DOI:

https://doi.org/10.70151/2jmg8q56

Keywords:

Duguetia furfuracea, phytochemistry, alkaloids, polyphenols, biological properties

Abstract

Duguetia furfuracea (A.St.–Hil.) Saff. has ancient descriptions in traditional medicine in the middle-western region of Brazil for multiple therapeutic uses and it is currently considered an invasive plant. The aim of this manuscript is to provide a review of published studies on botany, traditional uses, phytochemistry, biological effects and toxicology of D. furfuracea. Information was collected from databases Scielo, PubMed, Chemical Abstracts and Web of Science. There are several traditional uses of D. furfuracea, in treatment of rheumatism, menorrhagia, dysmenorrhea, pediculosis, renal colic, and stomachache. Based on a phytochemical investigation, over hundred compounds have been identified from the leaves, twigs, underground stem bark and wood of D. furfuracea, such as alkaloids, terpenes, flavonoids, phenolic acids and phenylpropanoids. This species present a broad spectrum of effects such as trypanocidal, leishmanicidal, larvicidal, antitumoral, anti-inflammatory, antimutagenic and cytoprotective. Data about the toxicity are limited, mainly for in vivo experiments. Phytochemical and pharmacological studies have demonstrated the therapeutic potential of D. furfuracea. However, the study of pharmacological mechanisms of its herbal medicinal product and isolated constituents should be further explored, since capsules containing material of this species have already been developed for renal colic.

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Author Biographies

  • Aline Aparecida Saldanha, Universidade Federal de São João del-Rei

    Laboratório de Farmacologia da Dor e Inflamação

    Laboratório de Farmacognosia/Química de Produtos Naturais

  • Niuane Thaís Alves Coelho, Universidade Federal de São João del-Rei

    Laboratório de Farmacognosia/Química de Produtos Naturais

  • Karina Aparecida Resende, Universidade Federal de São João del-Rei

    Laboratório de Farmacologia da Dor e Inflamação

  • Carlos Alexandre Carollo, Universidade Federal de Mato Grosso do Sul

    Laboratório de Produtos Naturais e Espectrometria de Massas (LAPNEM)

  • Denise Brentan da Silva, Universidade Federal de Mato Grosso do Sul

    Laboratório de Produtos Naturais e Espectrometria de Massas (LAPNEM)

  • Adriana Cristina Soares, Universidade Federal de São João del-Rei

    Laboratório de Farmacologia da Dor e Inflamação

  • João Máximo de Siqueira, Universidade Federal de São João del-Rei

    Laboratório de Farmacognosia/Química de Produtos Naturais

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Phytochemical profile, traditional uses, and biological activities of Duguetia furfuracea: A review. (2025). Revista Brasileira De Plantas Medicinais, 27(2025), e2025004. https://doi.org/10.70151/2jmg8q56