The potential use of phenolic compounds in the treatment of hair loss: a literature review
DOI:
https://doi.org/10.70151/n40pev13Keywords:
Alopecia, Clinical trial, Medicinal plants, Polyphenols, ReviewAbstract
Hair loss is a condition that affects both men and women, causing psychological and physical suffering. This literature review aimed to bring together in vivo studies and clinical trials related to the use of phenolic compounds, mainly tannins, flavonoids, and metabolites from the phenolic acid class to combat hair loss. The bibliographic search was carried out in the PubMed/MEDLINE and Scopus databases, using keywords such as “flavonoids”, “tannins”, “phenolic acid” and “hair loss”. Regarding the clinical trials included, three types of study were used (randomized, double-blind, and placebo control). All the compounds evaluated were obtained from medicinal plants, three tannins and one flavonoid. The formulations evaluated were three hair tonics and one lotion, and phenolic compounds from procyanidin class were present in almost all articles (n=3). The use of these compounds was related to the reported potent antioxidant and anti-inflammatory activity, which favor the anagen phase of hair, reducing reactive oxygen species and inflammation of hair follicles. Therefore, more studies are needed to promote and discuss the use of phenolic compounds for hair loss, mainly through randomized clinical trials. To contribute to the research and development of new medicines, polyphenols have several benefits and have a similar action to conventional medicines.
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