Do Crataegus pinnatifida capsules sold in Brazil undergo pharmaceutical quality control? Is there a quality control adopted in Brazil?
DOI:
https://doi.org/10.70151/mr1m1c57Keywords:
Thin layer chromatography, phytopharmaceutical products, total phenolic contentAbstract
The Chinese hawthorn, Crataegus pinnatifida, Rosaceae, is widely used in Traditional Chinese Medicine (TCM). As there is no Brazilian legislation to carry out the quality evaluation of this drug, this work aimed to carry out the quality control of C. pinnatifida capsules (Shan Zha), sold commercially in Brazil. Due to lack of reference standard, an extract of the C. pinnatifida fruits (EC) was prepared. The quality control of the fruits presented adequate botanical analysis of the fruits and presented macroscopic characteristics in accordance with Chinese Pharmacopoeia. For the fruits, the sample had no foreign matter and the total ash content was 0.724 ± 0.160%. The capsules showed adequate dose uniformity, moisture content of 14.75 ± 0.476%, total ash content of 1.51 ± 0.199%. The total flavonoid (TF) percentage was 0.012% for the dried extract of fruits and 0.005% for the Shan Zha capsules. This study highlights the importance of carrying out quality control to ensure the authenticity and quality of products that fall within the classification of supplements in Brazilian legislation and guide the dose calculation for C. pinnatifida products.
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